Effect of cytoglobin overexpression on extracellular matrix component synthesis in human tenon fibroblasts
نویسندگان
چکیده
منابع مشابه
Extracellular matrix elasticity modulates TGF-β-induced p38 activation and myofibroblast transdifferentiation in human tenon fibroblasts.
PURPOSE Extracellular matrix and the cytokine TGF-β influence scar formation in an interdependent fashion. In this study, the impact of extracellular matrix elasticity on TGF-β-induced signal transduction and myofibroblast transdifferentiation was examined. METHODS Primary human tenon fibroblasts were seeded on collagen-coated glass coverslips (rigid environment) or collagen or polyacrylamide...
متن کاملInhibition by a retinoic acid receptor γ agonist of extracellular matrix remodeling mediated by human Tenon fibroblasts
PURPOSE Scar formation is most frequently responsible for the failure of glaucoma filtration surgery. Retinoic acids are vitamin A derivatives that play diverse roles in development, immunity, and tissue repair. The effects of the retinoic acid receptor (RAR) γ agonist R667 on the contractility of human Tenon fibroblasts (HTFs) cultured in a three-dimensional collagen gel as well as on intraocu...
متن کاملHSP47 Deletion Inhibits TGF-β1 Stimulation on Proliferation and Collagen Synthesis of Human Tenon Fibroblasts
Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that is required for molecular maturation of various types of collagens. Many studies have shown a close association between increased expression of HSP47 and excessive accumulation of collagens in scar tissues of various human fibrotic diseases. However, the role of HSP47 in formation of scar after glaucoma filtration sur...
متن کاملThe effect of bevacizumab on human Tenon fibroblasts in ocular wound healing.
We thank Dr. Guzek for his comments on our paper published in the January issue of the journal. There may have been some misunderstanding of our methods and findings. It should be noted that we analyzed separately those patients who received monotherapy and whose corneal ulcers healed and those who either received combination therapy or whose ulcers did not heal. In the combination group, a var...
متن کاملGlucocorticoids regulate extracellular matrix metabolism in human vocal fold fibroblasts.
OBJECTIVES/HYPOTHESIS Given the recent emergence of encouraging efficacy data regarding the utility of intralesional glucocorticoid (GC) injection for a variety of vocal fold pathologies, we sought to describe the location and expression pattern of the GC receptors within the vocal folds and quantify the effects of GCs on vocal fold fibroblasts. STUDY DESIGN In vitro, in vivo. METHODS Immun...
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ژورنال
عنوان ژورنال: Biological Research
سال: 2019
ISSN: 0717-6287
DOI: 10.1186/s40659-019-0229-4