Effect of Cycas pectinata Seed Extract on Testicular Steroidogenesis in a Mouse Model

The seed of Cycas pectinata is widely used in traditional practices the Northeastern region India for diverse purposes along with improving testicular functions. Thus, it may be hypothesized that phytochemicals C. could modulate steroidogenesis. Therefore, we have investigated effects Pectinata extract (CPE) on steroidogenesis by using vivo and vitro approaches. We also performed molecular docking some steroidogenic markers based identified from our previous study. treatment CPE increased circulating estrogen decreased testosterone. showed secretion which can suggested due to an increase aromatase (CYP19A1) activity. Our results expression localization CYP19A1 were elevated CPE. accumulation cholesterol testis, enhance other like 3βHSD, StAR, LHR upregulated Twelve compounds exhibited binding energy range -10.0 -8.0 kcal/mol CYP19A1. data vitro, vivo, studies,