Effect of crocus sativus on gentamicin induced nephrotoxicity

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Effect of crocus sativus on gentamicin induced nephrotoxicity.

Crocus sativus, known as saffron, is used in folk medicine for treatment of different types of diseases, and its anti-inflammatory and free radical scavenging activities have been demonstrated. The present study evaluated gentamicin nephrotoxicity in saffron treated rats. Male Wistar rats (200-250 g) were treated with saffron (40 or 80 mg/k/d) for 10 days, or saffron (40 or 80 mg/ kg/d) for 10 ...

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Protective effect of crocin on gentamicin-induced nephrotoxicity in rats

Objective(s): Gentamicin is used for the treatment of Gram-negative bacterial infections. However, gentamicin administration is limited because of nephrotoxicity. The aim of the present study was to evaluate the protective effect of crocin against gentamicin-induced nephrotoxicity in rats. Materials and Methods: Thirty two male Wistar rats received gentamicin (100 mg/kg, IP), with or without c...

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Effect of normobaric hyperoxia on gentamicin-induced nephrotoxicity in rats

Objective(s):Gentamicin sulphate (GS) nephrotoxicity seems to be related to the generation of reactive oxygen species. There is evidence that oxygen preconditioning increases the activity of antioxidant enzymes. Materials and Methods: Forty eight female rats were divided into 6 groups (n=8) as follows: group 1 was the control, group 2 received daily GS, groups 3,4 and 5 received oxygen 2 hr/day...

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Protective Effect of Safranal against Gentamicin-Induced Nephrotoxicity in Rat

Gentamicin is an important aminoglycoside antibiotic. However its use is limited to serious and life threatening gram negative infections, because of its high nephrotoxicity potential in patients. There are reports that safranal, the active ingredient of saffron with antioxidant properties, exerts protective effect against ischemic injuries occurred by certain nephrotoxins including gentamicin....

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Reno-protective effect of Rheum turkestanicum against gentamicin-induced nephrotoxicity

Objective(s): Gentamicin belongs to the family of aminoglycoside antibiotics and is a preferred drug in developing countries because of its low cost, availability, and potent effects against bacterial. However, gentamicin can induce nephrotoxicity. In this research, hydroalcoholic extract of Rheum turkestanicum was used against gentamicin- induced nephrotoxicity. Rheum turkestanicum is used aga...

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ژورنال

عنوان ژورنال: Biological Research

سال: 2010

ISSN: 0716-9760

DOI: 10.4067/s0716-97602010000100010