Effect of colloidal silicon dioxide and moisture on powder flow properties: Predicting in-process performance using image-based analysis

Abstract The effect of colloidal silicon dioxide (CSD) on powder flow properties poor-flowing excipient lactose 200 M was investigated. Binary mixtures different ratios CSD as glidant were examined using a modern image-based measuring technique. Special attention placed to subtle variations in from small changes concentration (0.025% w/w). Understanding the modes interaction particles and their effects flowability method predicted die filling performance during tablet manufacture. In addition, importance moisture content empirically underlined. A more efficient range detected 0.10 0.50% w/w most tested conditions, which revealed significant improvement compared higher amounts typically handled pharmaceutical industry.