Effect of cladribine therapy on lung cysts in pulmonary Langerhans cell histiocytosis
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منابع مشابه
Effect of cladribine therapy on lung cysts in pulmonary Langerhans cell histiocytosis
Cladribine therapy may be beneficial in advanced forms of pulmonary Langerhans cell histiocytosis, even that with multiple cystic changes http://ow.ly/yeLr30i0Tt6.
متن کاملchemotherapy cell histiocytosis improved by cladribine Progressive diffuse pulmonary Langerhans
UK and USA has serious side effects because of systemic dissemination of small particles. They omitted, however, an important experimental study which used larger talc particles (ie, the talc currently used in Europe for .70 years) and clearly showed that this talc does not disseminate in organs, unlike previous studies using American or Brazilian talc. This explains why many European respirato...
متن کاملCladribine activity in adult langerhans-cell histiocytosis.
Langerhans-cell histiocytosis (LCH) results from the accumulation of tissue histiocytes derived from the same progenitor cells as monocytes. Because cladribine is potently toxic to monocytes, we conducted a phase II trial of cladribine. Cladribine was administered to 13 LCH patients at 0.14 mg/kg per day by 2-hour intravenous infusion for 5 consecutive days, every 4 weeks for a maximum of six c...
متن کاملEffectiveness of cladribine therapy in patients with pulmonary Langerhans cell histiocytosis
BACKGROUND Pulmonary Langerhans cell histiocytosis (PLCH) is a rare disorder characterised by granulomatous proliferation of CD1a-positive histiocytes forming granulomas within lung parenchyma, in strong association with tobacco smoking, and which may result in chronic respiratory failure. Smoking cessation is considered to be critical in management, but has variable effects on outcome. No drug...
متن کاملPulmonary langerhans cell histiocytosis
Pulmonary Langerhans' cell histiocytosis (PLCH) remains an important diagnostic consideration in the differential diagnosis of diffuse infiltrative lung disease, particular among smokers. This review highlights recent progress in our understanding of the etiology, clinical presentation, and diagnostic and therapeutic approaches to this unusual lung disorder. Evolving studies strongly link the b...
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ژورنال
عنوان ژورنال: ERJ Open Research
سال: 2018
ISSN: 2312-0541
DOI: 10.1183/23120541.00089-2017