Effect of atorvastatin combined with interventional therapy for acute myocardial infarction

نویسندگان

چکیده

Purpose: To evaluate the coronary thrombolytic effect of atorvastatin plus percutaneous intervention (PCI) for treatment acute myocardial infarction.Methods: From April 2019 to October 2020, 88 patients with infarction who were treated in Zhangqiu District People's Hospital randomly assigned receive either PCI (conventional group) or (combined group). Myocardial injury index, TnI, and creatine kinase isoenzyme (CK-MB) used determine injury, while serum cTnI was determined using enzyme-linked immunosorbent assay (ELISA). Creatine levels by immunosuppression method. Cardiac ultrasound measure compare left ventricular end-diastolic diameter (LVEDD), ejection fraction (LVEF), end-systolic (LVESD) before after two groups. Blood lipid drug administration, respectively, highdensity lipoprotein cholesterol (HDL-C) a colorimetric Total (TC) triacylglycerol (TG) assessed an enzymatic method, low-density (LDL-C) biochemical Serum B-type natriuretic peptide (BNP), c-reactive-protein (CRP), interleukin (IL)-6 evaluated automatic analyzer. The incidence adverse reactions during treatment, including creatinine elevation, muscle pain, gastrointestinal their frequencies computed.Results: combined group exhibited significantly lower indices when compared conventional (p < 0.05). Atorvastatin resulted higher dimension (LVEDD) as well alone After showed healthier (LDL-C), total (TC), high-density (HDL-C), triglyceride 0.05).Conclusion: mitigates lowers cardiac function, indices, B type C-reactive-protein levels. It also reduces events treatment. Thus, this therapeutic strategy has potentials application management infarction.

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ژورنال

عنوان ژورنال: Tropical Journal of Pharmaceutical Research

سال: 2023

ISSN: ['1596-5996', '1596-9827']

DOI: https://doi.org/10.4314/tjpr.v21i12.24