Effect of amantadine and imipramine on immunological parameters of rats subjected to a forced swimming test
نویسندگان
چکیده
منابع مشابه
Effect of co-administration of fluoxetine and amantadine on immunoendocrine parameters in rats subjected to a forced swimming test.
Considerable attention has been paid to a possible role of immunological dysregulation in the pathogenesis of depression. It has been reported that combined administration of antidepressant drugs and the non-competitive NMDA receptor antagonist amantadine reduces immobility time in the forced swimming test (FST). Moreover, preliminary clinical data show that such a combination of drugs has a be...
متن کاملSynergistic effect of imipramine and amantadine in the forced swimming test in rats. Behavioral and pharmacokinetic studies.
Our previous studies demonstrated that joint administration of a tricyclic antidepressant drug, imipramine (IMI) with the uncompetitive antagonist of NMDA receptor, amantadine (AMA), produced stronger "antidepressant" effect in the forced swimming test (Porsolt's test) than the treatment with either of drugs given alone. Since it has been suggested that, in addition to their other functions, do...
متن کاملConcomitant administration of fluoxetine and amantadine modulates the activity of peritoneal macrophages of rats subjected to a forced swimming test.
Recent studies show that administration of a non-competitive NMDA receptor antagonist, amantadine (AMA), potentiates the action of antidepressant drugs. Since antidepressants may modulate functioning of the immune system and activation of a pro-inflammatory response in depressive disorders is frequently reported, the aim of the present study was to examine whether a combined administration of A...
متن کاملEffect of Smilax China Linn on Testicular Antioxidant Activity and Spermatological Parameters in Rats Subjected to Forced Swimming Stress
The aim of the present study was to investigate the potential benefits of ethanolic extract of Smilax china Linn. on testicular antioxidant activity and spermatological parameters in rats subjected to forced swimming stress. Animals of the experimental groups except vehicle control were subjected to forced swimming stress (FSS) 15 min/day for 52 days. Animals were pretreated with two doses of e...
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ژورنال
عنوان ژورنال: The International Journal of Neuropsychopharmacology
سال: 2005
ISSN: 1461-1457,1469-5111
DOI: 10.1017/s1461145705005663