Effect of adding selegiline to levodopa in early, mild Parkinson's disease
نویسندگان
چکیده
منابع مشابه
Effect of adding selegiline to levodopa in early, mild Parkinson's disease. Formal systematic review of data on patients in all relevant trials is required.
Editor—The increased death rate with selegiline in the Parkinson’s Disease Research Group’s trial highlights the problem of interpreting the results of a small trial in isolation. Ben-Shlomo et al emphasised the internal consistency of this finding, which is not surprising because much of the original data were reanalysed. The hazard ratio was lower than in the original report (1.32 v 1.57), wh...
متن کاملInvestigation by Parkinson's Disease Research Group of United Kingdom into excess mortality seen with combined levodopa and selegiline treatment in patients with early, mild Parkinson's disease: further results of randomised trial and confidential inquiry.
OBJECTIVE To determine whether the excess mortality observed in patients who received both levodopa and selegiline in a randomised trial could be explained by revised diagnosis of Parkinson's disease, autonomic or cardiovascular effects, more rapid disease progression, or drug interactions. DESIGN Open randomised trial and blind comparison and reclassification of the cause of death of patient...
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Background & Objective: Inflammatory bowel diseases (IBDs) represent serious chronic auto-inflammatory conditions, affecting the alimentary tract. The beneficial effect of dexpanthenol has been observed on some inflammatory conditions. Here, the therapeutic potential of combined dexpanthenol and prednisolone in alleviating the symptoms of the animal model of IBD was investigated. Materials & M...
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BACKGROUND The effect of initiation of levodopa therapy on the memory functions in patients with Parkinson's disease remains poorly understood. AIMS To evaluate the effect of initiation of levodopa therapy on memory, in patients with early Parkinson's disease. SETTINGS AND DESIGN Prospective case control study. MATERIALS AND METHODS Seventeen patients with early Parkinson's disease were e...
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ژورنال
عنوان ژورنال: BMJ
سال: 1998
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.317.7172.1586