Effect of a novel tyrosine kinase inhibitor nintedanib on bFGF and VEGF concentrations in a rabbit retinal vein occlusion model
نویسندگان
چکیده
AIM: To evaluate whether a novel tyrosine kinase inhibitor nintedanib could inhibit basic fibroblast growth factor (bFGF) and vascular endothelial (VEGF) simultaneously for retinal disease in vivo. METHODS: After laser induced rabbit vein occlusion (RVO) model was made, 0.5 mg of injected intravitreally the left eye on third day while right as control. Intracameral samples were taken before treatment days 1, 3, 7, 14, 21, 28 after treatment. Enzyme-linked immunosorbent assay (ELISA) used to test bFGF VEGF-A concentrations aqueous humor. RESULTS: Both rose significantly both eyes. In control concentration peaked 14th dropped rapidly soon day. nintadanib injection study eye, showed significant reduction 4th (7th treatment) when compared kept low level following several weeks. CONCLUSION: Intravitreal can expression VEGF process RVO certain extent, which is expected become new method diseases or fibrotic diseases.
منابع مشابه
Sulfur Mustard Exposure and Non-Ischemic Central Retinal Vein Occlusion
A 41-year-old man was referred with a complaint of visual loss in his left eye and his best corrected visual acuity was 20/80. Slit lamp examination showed arborizing conjunctival vessels and dry eye. Fundus examination and fluorescein angiography revealed a non-ischemic central retinal vein occlusion. Cardiovascular, rheumatologic, and hematologic work up showed no abnormal findings. An ascert...
متن کاملAnti-VEGF in treatment of central retinal vein occlusion.
Macular edema along with macular ischemia is responsible for decreased visual acuity in central retinal vein occlusion. Bevacizumab (Avastin, Genentech) blocks vascular endothelial growth factor (VEGF) induced hyperpermeability of blood vessels. In this prospective case series we investigated the efficacy of anti-VEGF treatment in reduction of central retinal thickness (CRT) and improvement in ...
متن کاملeffect of sub-grid scales on large eddy simulation of particle deposition in a turbulent channel flow
چکیده ندارد.
15 صفحه اولInduction of Branch Retinal Vein Occlusion by Photodynamic Therapy with Rose Bengal in a Rabbit Model
متن کامل
wuthering heights and the concept of marality/a sociological study of the novel
to discuss my point, i have collected quite a number of articles, anthologies, and books about "wuthering heights" applying various ideas and theories to this fantastic story. hence, i have come to believe that gadamer and jauss are rightful when they claim that "the individaul human mind is the center and origin of all meaning," 3 that reading literature is a reader-oriented activity, that it ...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Ophthalmology
سال: 2023
ISSN: ['2227-4898', '2222-3959']
DOI: https://doi.org/10.18240/ijo.2023.09.11