Efek Inhibitor Proteasom Terhadap Gambaran Histopatologi Jantung pada Tikus yang diinduksi Aterosklerosis

Proteasome inhibitors are compounds that can inhibit the proteasome pathway in carrying out its functions. have a beneficial effect due to their anti-inflammatory properties. The inhibitor used this study was bortezomib. This aimed analyze of on cardiac histopathology atherosclerosis-induced rats. male Rattus novergicus Wistar strain which divided into 3 groups, namely control group, group and given results obtained mean scores edema, inflammation necrosis atherosclerosis were bortezomib at dose 50 g/kgBW less than group. Theese difference statistically significant (p<0.05). concluded administration reduce Impact atherosclerotic lesions heart muscle.