Edoxaban Dosing Time Affects Blood Coagulation Inhibition in Rats

Blood Coagulation Changes in Rats Fed High Fat Diets.

• For the past fift3 j-ears investigators have attempted to show a relationship between high lipid diets and the production of atherosclerosis and thrombosis. Recently interest has shifted from a consideration of diets in the pathogenesis of atherosclerosis to a study of their association with alterations in the levels of coagulation factors as a possible cause of thrombus formation, a possibil...

Inhibiting platelet-stimulated blood coagulation by inhibition of mitochondrial respiration.

Platelets are important mediators of blood coagulation that lack nuclei, but contain mitochondria. Although the presence of mitochondria in platelets has long been recognized, platelet mitochondrial function remains largely unaddressed. On the basis of a small amount of literature that suggests platelet mitochondria are functional, we hypothesized that the inhibition of platelet mitochondria di...

Lages coagulation mechanism in blood obtained from bleeding time wounds

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Comparison of the blood coagulation profiles of ferrets and rats.

The aim of this study was to examine the blood coagulation profiles of ferrets and compare them with those of rats. The ferret activated partial thromboplastin time (aPTT) was slightly longer than the rat aPTT. In contrast, the ferret prothrombin time and thrombin time were profoundly shorter than the corresponding rat values. The fibrinogen level in ferret plasma was 2 times higher than that i...

Changes in blood coagulation.