Editorial: PPI-responsive oesophageal eosinophilia and long-term PPI treatment
نویسندگان
چکیده
منابع مشابه
Food allergy and PPI-responsive esophageal eosinophilia
Background Eosinophilic esophagitis (EoE) is considered a chronic condition mediated by immune reaction to food and/or environmental allergens. Though first recognized decades ago, the characterization of EoE is ongoing and an important aspect of this process is the distinction between EoE and other forms of esophageal eosinophilia [1,2]. One group of patients exhibit marked esophageal eosinoph...
متن کاملDistinguishing eosinophilic esophagitis from gastroesophageal reflux disease upon PPI refractoriness: what about PPI-responsive esophageal eosinophilia?
on PPI therapy [3–7] , leading to the description of a new potential disease phenotype in the 2011 updated guidelines, i.e. PPI-responsive esophageal eosinophilia (PPIRee) [8] . Whether these patients represent a sub-phenotype of GERD, EoE or a combined mechanism of both disorders remains unknown. In the aforementioned reports neither histological specific features [6] , pH esophageal monitorin...
متن کاملDiminishing Effectiveness of Long-Term Maintenance Topical Steroid Therapy in PPI Non-Responsive Eosinophilic Esophagitis
OBJECTIVES While topical corticosteroids are first-line therapy for eosinophilic esophagitis (EoE), the data regarding long-term effectiveness are lacking. We aimed to determine long-term histologic and endoscopic outcomes of maintenance therapy in EoE steroid responders. METHODS We performed a retrospective study of adults with EoE at UNC Hospitals who had initial histologic response (<15 eo...
متن کاملIdentifying protein complexes and functional modules - from static PPI networks to dynamic PPI networks
Cellular processes are typically carried out by protein complexes and functional modules. Identifying them plays an important role for our attempt to reveal principles of cellular organizations and functions. In this article, we review computational algorithms for identifying protein complexes and/or functional modules from protein-protein interaction (PPI) networks. We first describe issues an...
متن کاملClopidogrel and proton pump inhibitor (PPI) interaction: separate intake and a non-omeprazole PPI the solution?
BACKGROUND Dual therapy with aspirin and clopidogrel increases the risk of gastrointestinal bleeding. Therefore, co-therapy with a proton pump inhibitor (PPI) is recommended by most guidelines. However, there are warnings against combining PPIs with clopidogrel because of their interactions with cytochrome P450 isoenzyme 2C19 (CYP2C19). METHODS The effects of the combined or separate intake o...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2016
ISSN: 0269-2813
DOI: 10.1111/apt.13528