Editorial: Parkinson's disease: cell vulnerability and disease progression

Editorial: Parkinson's disease: cell vulnerability and disease progression

The hallmark of Parkinson Disease (PD) is the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc) and the consequent striatal dopamine (DA) deficiency, although it is well recognized that neurodegeneration in PD goes beyond the SNc. Major advances have occurred in recent years on the molecular and pathophysiological basis of PD, however there remain many questions a...

Rab11 in Disease Progression

Membrane/ protein trafficking in the secretory/ biosynthetic and endocytic pathways is mediated by vesicles. Vesicle trafficking in eukaryotes is regulated by a class of small monomeric GTPases the Rab protein family. Rab proteins represent the largest branch of the Ras superfamily GTPases, and have been concerned in a variety of intracellular vesicle trafficking and different intracellular sig...

Editorial: Sickle cell disease.

Although sickle cell disease was designated by a number of onomatopoetic native names in Africa for centuries ( 1 ), it was clearly described as a distinct hematological and clinical entity in the United States in 1910 (2). During the next three decades, a considerable body of descriptive, clinical, and genetic data was slowly accumulated; but progress accelerated after protein chemists such as...

Editorial: “Disease-Only” alleles and genotypes in complex disorders?

rab11 in disease progression

membrane/ protein trafficking in the secretory/ biosynthetic and endocytic pathways is mediated by vesicles. vesicle trafficking in eukaryotes is regulated by a class of small monomeric gtpases the rab protein family. rab proteins represent the largest branch of the ras superfamily gtpases, and have been concerned in a variety of intracellular vesicle trafficking and different intracellular sig...