Editorial: Gastrointestinal Hormones

Editorial: Natriuretic Hormones

The link between renal sodium excretion and body fluid volumes has been a topic of interest since the early days of renal physiology (1). Glomerular filtration rate (GFR) and aldosterone were the first two controllers of renal sodium excretion to be recognized. A “third factor” was discovered when de Wardener and colleagues showed that volume expansion natriuresis still occurred in dogs given s...

Gut hormones in gastrointestinal disease.

Considerable advances have been made in the understanding of the physiology of gut hormones. Thus, knowledge of the mechanisms of release and of the actions of many of the hormones is rapidly expanding. The known clinical importance of gut hormones is at present confined only to the excess production of gastrin, VIP, and pancreatic glucagon by endocrine tumours. The role of these three and the ...

Gastrointestinal Hormones: Introduction and Index

Chemistry, isolation and purification of gastrointestinal hormones.

The isolation in the early 1960s (Gregory & Tracy, 1975; Jorpes & Mutt, 1973) from porcine intestinal and gastric antral tissues of the classical gastrointestinal hormones gastrin, secretin and cholecystokinin, the latter having also the properties ascribed to pancreozymin, confirmed the long-suspected peptide nature of these substances. It then seemed-for a time-that the field of gastrointesti...

SnapShot: Hormones of the Gastrointestinal Tract

Specialized endocrine cells secrete a variety of peptide hormones all along the gastrointestinal (GI) tract, making it one of the largest endocrine organs in the body. Nutrients and developmental and neural cues trigger the secretion of gastrointestinal (GI) hormones from specialized endocrine cells along the GI tract. These hormones act in target tissues to facilitate digestion and regulate en...