Editorial: DNA damage & immunity

Editorial: DNA Damage and Inflammation under Stress

The DNA damage response, immunity and cancer.

The genome is constantly exposed to exogenous DNA damaging events in the form of radiation, viral infection and chemicals. Endogenous processes such as DNA replication and free radical formation also threaten the integrity of the genome. DNA damage is directly deleterious to cells and also promotes tumorigenesis. Eukaryotic organisms have evolved a signaling pathway, called the DNA damage respo...

Guest editorial: fanconi anemia and the DNA damage response.

Every cell in our body other than red blood cells has a genome, the stability of which is crucial for life. The DNA is precisely replicated during cell proliferation, and is stably maintained, even after terminal differentiation, as a repository of information that orchestrates the cell’s metabolism. Unfortunately, our world is full of potential threats to genomic stability. DNA may degrade spo...

Editorial: Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response

Radiation track and DNA damage