Editorial: Curve progression

Editorial: Z-curve Applications in Genome Analysis

It is my pleasure to be a guest editor for the special issue on Z-curve applications in genome analysis. We are now living in the genomic era and facing an avalanche of sequencing information; two decades ago, however, not a single genome sequence of free-living organisms was available. The progress in DNA sequencing technology, in terms of both speed and cost, has been remarkable. The discover...

Editorial Review CKD progression: a risky business

In 2006, the very strong association between obesity and end-stage kidney disease (ESKD) risk was demonstrated among 320 252 adults enrolled in the Kaiser Permanente health system. These individuals volunteered for a screening health checkup between 1964 and 1985 and were followed until death, dialysis initiation or until 31 December 2000. Class III obesity or body mass index (BMI) ≥40 kg/m wer...

Editorial: Parkinson's disease: cell vulnerability and disease progression

The hallmark of Parkinson Disease (PD) is the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc) and the consequent striatal dopamine (DA) deficiency, although it is well recognized that neurodegeneration in PD goes beyond the SNc. Major advances have occurred in recent years on the molecular and pathophysiological basis of PD, however there remain many questions a...

Convex side muscular activity and progression of scoliotic curve

Results Increased paraspinal muscular activity at convex side of scoliotic curve is well known and documented finding. Main directions of research are related to structural changes in muscles and regulation of muscular contractility. In most cases the myopathic changes are considered as the consequence of the postural deformity. Very little information is available on the mechanisms by which su...

University of Groningen Prediction of Curve Progression in Idiopathic Scoliosis