منابع مشابه
Standard Multiple and Single Daily Dosing of Amikacin in Premature Infants
Background: Bacterial sepsis is highly prevalent among premature infants. Amikacin is an antibiotic widely recommended for the treatment of neonatal sepsis, one of the consequences of which might be nephrotoxicity. The present study aimed to compare the efficacy and nephrotoxicity of multiple daily dosing (MDD) and once-daily dosing (ODD) of amikacin in preterm infants suspected of sepsis. Met...
متن کاملSuccessful pregnancy outcome in paroxysmal nocturnal hemoglobinuria (PNH) following escalated eculizumab dosing to control breakthrough hemolysis
Pregnancy in women with paroxysmal nocturnal hemoglobinuria (PNH) is associated with increased maternal and fetal morbidity and mortality. There is limited published experience regarding therapy of PNH during pregnancy. We describe a case of a 30 year old female with hypoplastic myelodysplastic syndrome and PNH. After two years of treatment with eculizumab, she became pregnant. She developed br...
متن کاملTherapeutic drug monitoring of eculizumab: Rationale for an individualized dosing schedule
The annual cost of eculizumab maintenance therapy in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic-uremic syndrome (aHUS) exceeds $300,000 per patient. A better understanding of eculizumab pharmacokinetics and subsequent individual dose adjustment could reduce this cost. We measured the trough eculizumab concentration in 9 patients with maintenance therapy (aHUS, n = 7; PNH, ...
متن کاملPopulation pharmacokinetics of gentamicin and dosing optimization for infants.
The aim of this study was to characterize and validate the population pharmacokinetics of gentamicin in infants and to determine the influences of clinically relevant covariates to explain the inter- and intraindividual variabilities associated with this drug. Infants receiving intravenous gentamicin and with routine therapeutic drug monitoring were consecutively enrolled in the study. Plasma c...
متن کاملEculizumab: another breakthrough.
PNH is a clonal hematopoietic stem cell disease associated with a complementdependent hemolytic anemia. The disease manifests after the expansion of a multipotent hematopoietic stem cell that acquires a mutation of the PIGA gene. The PIGA gene product is required for the biosynthesis of glycophosphatidylinositol anchors, a glycolipid moiety that attaches dozens of proteins to the plasma membran...
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ژورنال
عنوان ژورنال: Indian Journal of Nephrology
سال: 2018
ISSN: 0971-4065
DOI: 10.4103/ijn.ijn_310_16