Ectopic pregnancies: Catch them early, treat them wisely!

Make them, break them, and catch them: studying rare ubiquitin chains.

Two studies in this issue, Kristariyanto et al. (2015) and Michel et al. (2015), describe innovative ways to produce large quantities of atypical K29 and K33 ubiquitin chains and report structures and mechanisms of chain-specific recognition.

Wear them, forget them.

Gotta (efficiently) catch them all: Pokémon GO meets Orienteering Problems

In this paper a new routing problem referred to as the Generalized Clustered Orienteering Problem (GCOP) is studied. The problem is motivated by the mobile phone game Pokémon GO, an augmented reality game for mobile devices holding a record-breaking reception: within the first month of its release, more than 100 million users have installed the game on their device. The game’s immense popularit...

Early reading for low-SES minority language children: an attempt to 'catch them before they fall'.

Minority language and low socioeconomic status (SES) students are at high risk for language and learning disabilities. In an attempt to 'catch them before they fall', an early reading project was initiated in four kindergarten classes, in a low-SES bilingual school (English/French as a second language), where minority language children form a majority. The project included: (1) teaching reading...

Off-label prescriptions: how to identify them, frame them, announce them and monitor them in practice?

Following the Mediator crisis and the passage of the Health and Safety Law of December 2011, off-label prescriptions are a real concern shared by all those involved in healthcare system. Off-label, in the strictest sense of the term, is defined as all prescriptions that do not correspond to the summary of product characteristics (SPC), particularly those that fail to comply with the indications...