ECM: chemoattraction but not adhesion

not intervention but participation

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Genome-Wide Gene Expression Analysis in Cancer Cells Reveals 3D Growth to Affect ECM and Processes Associated with Cell Adhesion but Not DNA Repair

Cell morphology determines cell behavior, signal transduction, protein-protein interaction, and responsiveness to external stimuli. In cancer, these functions profoundly contribute to resistance mechanisms to radio- and chemotherapy. With regard to this aspect, this study compared the genome wide gene expression in exponentially growing cell lines from different tumor entities, lung carcinoma a...

trigeminal neuralgia-divided but not classified

ECM signals ECM degradation

W hen Caroline Damsky moved her lab to the University of California, San Francisco, in 1985, she knew she would have an instant colleague in Zena Werb. There was a natural connection between their work. That connection would be refl ected in their discoveries, which delineated an integrin-mediated pathway from the extracellular matrix (ECM) outside the cell to the internal, gene-expressing life...

Intercellular adhesion molecule-1 is required for chemoattractant-induced leukocyte adhesion in resting, but not inflamed, venules in vivo.

The leukocyte integrins LFA-1 and Mac-1 bind to endothelial intercellular adhesion molecule-1 (ICAM-1). Leukocyte adhesion induced by micropipette injection of formylmethionylleucylphenylalanine (fMLP) or macrophage inflammatory protein 2 (MIP-2) next to a venule in the exteriorized mouse cremaster muscle was almost completely blocked after intravenous injection of the ICAM-1 mAb YN-1. In contr...