Ebola therapies: an unconventionally calculated risk

An application of calculated fuzzy risk

In this paper, we use the interior-outer-set model to calculate the risk of crop flood and order farming alternatives for Huarong County, China, where only a small sample of eight observations is available. Any risk assessment from the data must be imprecise. The risk calculated by this suggested model is a particular case among imprecise probabilities, called possibility–probability distributi...

Unconventional myosins acting unconventionally.

Unconventional myosins are proteins that bind actin filaments in an ATP-regulated manner. Because of their association with membranes, they have traditionally been viewed as motors that function primarily to transport membranous organelles along actin filaments. Recently, however, a wealth of roles for myosins that are not obviously related to organelle transport have been uncovered, including ...

Evaluating Ebola therapies--the case for RCTs.

T worst Ebola epidemic in history is ongoing. With the number of deaths from Ebola virus disease (EVD) already in the thousands and predicted to rise to tens of thousands,1 the situation is tragic. No treatments have yet been shown to be safe and effective in patients with EVD. Some candidate therapies have shown benefit in animal models of infection, and others have shown activity against cert...

Evaluating novel therapies during the Ebola epidemic.

The Ebola hemorrhagic fever outbreak inWest Africa poses acute and novel challenges for health policy and researchethics. Facedwith anexceptionally virulent infectious agent, limited resources, and danger to health workers, local and international authorities struggle to deployprovenpublichealth techniques thatcan limit the spread of the disease.1 In themidst of the crisis, experimental interve...

Using the Untested Ebola Drug in Ebola Affected Patients: An Ethical Dilemma