Easy passage: Germline transgenesis in frogs
نویسندگان
چکیده
منابع مشابه
“ What ’ s wrong with my monkey ? ” 1 Ethical perspectives on germline transgenesis in 2 marmosets
15 16 17 The birth of the first transgenic primate to have inherited a transgene from its parents 18 opens the possibility to set up transgenic marmoset colonies, as these monkeys are small 19 and relatively easy to keep and breed in research facilities. The prospect of transgenic 20 marmoset models of human disease, readily available in the way that transgenic 21 laboratory mice are currently,...
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Functional studies will facilitate characterization of role and essentiality of newly available genome sequences of the human schistosomes, Schistosoma mansoni, S. japonicum and S. haematobium. To develop transgenesis as a functional approach for these pathogens, we previously demonstrated that pseudotyped murine leukemia virus (MLV) can transduce schistosomes leading to chromosomal integration...
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The ability to manipulate the genome of organisms at will is perhaps the single most useful ability for the study of biological systems. Techniques for the generation of transgenics in the nematode Caenorhabditis elegans became available in the late 1980s. Since then, improvements to the original approach have been made to address specific limitations with transgene expression, expand on the re...
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Although the mouse remains the species of choice for most transgenic experimentation, it may be preferable or even necessary to use alternative species for certain applications. We review the strategies by which transgenic technology has been applied to other animals, specifically, the rat, rabbit, pig, sheep, goat, and cow. Additionally, we outline the potential applications of alternative tra...
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The production of transgenic animals has many biotechnological applications; however, available techniques still remain inefficient. This review summarizes the contributions of our group to transgenesis in domestic animal. One of the most traditional transgenesis techniques in farm animals is somatic cell nuclear transfer using genetically modified somatic cells. Using this technique, we produc...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1999
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.96.25.14189