Early mucosal changes in Crohn's disease.

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Early mucosal changes in Crohn's disease.

Aphthoid ulceration has been regarded as an early macroscopic feature of Crohn's disease, yet the cause of this mucosal lesion is unknown. Examination of areas of apparently normal and non-inflamed bowel in Crohn's disease has allowed the identification of mucosal changes which occur before macroscopic and microscopic ulceration. Thirty five resection specimens from patients with Crohn's diseas...

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1Department of Medicine, 2Department of coeliac patients on a Medical Microbiology, University of Turku, Turku, 3Department of Pediatrics, University Hospital of Tampere and Institute of Medical gluten-free diet Technology, University of Tampere, Tampere, 4Central Laboratory, University Hospital of Turku, 5Turku City Hospital, Turku, 6MediCity Research Laboratory and Lähteenoja H, Toivanen A, V...

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Derek Jewell Professor of Gastroenterology, Gastroenterology Unit, Radcliffe Infirmary, Oxford, OX2 6HE, UK. Tel: +44 (0) 1865 224829; Fax: +44 (0) 1865 790792; E-mail: [email protected] The genetics of inflammatory bowel disease (IBD) is an area of enormous topical interest. Crohn’s disease is one of the first polygenic diseases in which a susceptibility gene (NOD2 ) ...

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ژورنال

عنوان ژورنال: Gut

سال: 1993

ISSN: 0017-5749

DOI: 10.1136/gut.34.3.375