Early Monitoring Response to Therapy in Patients with Brain Lesions Using the Cumulative SUV Histogram

Gamma Knife treatment is an alternative to traditional brain surgery and whole-brain radiation therapy for treating cancers that are inaccessible via conventional treatments. To assess the effectiveness of treatments, functional imaging can play a crucial role. The aim this study evaluate new prognostic indices perform early assessment response using positron emission tomography imaging. parameters currently used in nuclear medicine assessments be affected by statistical fluctuation errors and/or cannot provide information on tumor extension heterogeneity. overcome these limitations, Cumulative standardized uptake value (SUV) Histogram (CSH) Area Under Curve (AUC) were evaluated obtain additional response. For purpose, absolute level [11C]-Methionine (MET) was measured its heterogeneity distribution within lesions calculating CSH AUC indices. show good agreement with patient outcomes after Furthermore, no relevant correlations found between those usually environment. could useful tool assessing responses therapy.