Early-Life Exposure to Dimethoate-Induced Reproductive Toxicity: Evaluation of Effects on Pituitary-Testicular Axis of Mice

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Early-life exposure to dimethoate-induced reproductive toxicity: evaluation of effects on pituitary-testicular axis of mice.

In utero and lactational exposure to organophosphate dimethoate exerted toxic impact on the reproductive system of male mice. Pregnant mice were exposed to 4, 8, and 16 mg/kg of the pesticide, the sublethal doses (2.5, 5, and 10% of Lethal Dose(50) [LD(50)]), via gavaging from gestation day (GD) 6 to postnatal day (PND) 21. The effects on the male reproductive system were evaluated at two stage...

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ژورنال

عنوان ژورنال: Toxicological Sciences

سال: 2009

ISSN: 1096-6080,1096-0929

DOI: 10.1093/toxsci/kfp204