Early immune responses and prognostic factors in children with COVID-19: a single-center retrospective analysis

Abstract Background Early diagnostic indicators and the identification of possible progression to severe or critical COVID-19 in children are unknown. To investigate immune characteristics early SARS-CoV-2 infection key prognostic factors for COVID-19, a retrospective study including 121 with was conducted. Peripheral blood lymphocyte subset counts, T cell-derived cytokine concentrations, inflammatory factor routine counts were analyzed statistically at initial presentation. Results The natural killer cell decreased increasing disease severity. Group III (critical cases) had higher Th/Tc ratio than groups I II (common cases); group B count III. IL-6, IL-10, IFN-?, SAA, procalcitonin levels increased Hemoglobin concentration, RBC eosinophil Groups significantly lower I. T, Th, Tc, RBC, hemoglobin relatively high contribution area under curve values. Conclusions Decreased IL-6 IL-10 valuable indices diagnosis disease. reduced Th Tc cells ferritin, procalcitonin, SAA this stage may be closely associated systemic storm caused by dysregulation.