Early Identification of Chronic Lung Allograft Dysfunction: The Need of Biomarkers

Chronic lung allograft dysfunction: evolving practice.

PURPOSE OF REVIEW Chronic lung allograft dysfunction (CLAD) was recently introduced as an overarching term covering different phenotypes of chronic allograft dysfunction, including obstructive CLAD (bronchiolitis obliterans syndrome), restrictive CLAD (restrictive allograft syndrome) and graft dysfunction due to causes not related to chronic rejection. In the present review, we will highlight t...

Physiology of chronic lung allograft dysfunction: back to the future?

Chronic lung allograft dysfunction (CLAD) is, in one sense, a term without a true consensus definition, although its common usage in the field of lung transplantation implies a base understanding throughout the community that it describes a lung allograft that does not work (well) [1]. There appears to be general agreement that CLAD most commonly occurs in a time-dependent fashion after transpl...

Chronic lung allograft dysfunction following lung transplantation: challenges and solutions

Urine proteomics to detect biomarkers for chronic allograft dysfunction.

Despite optimal immunosuppressive therapy, more than 50% of kidney transplants fail because of chronic allograft dysfunction. A noninvasive means to diagnose chronic allograft dysfunction may allow earlier interventions that could improve graft half-life. In this proof-of-concept study, we used mass spectrometry to analyze differences in the urinary polypeptide patterns of 32 patients with chro...

Prediction of chronic lung allograft dysfunction: a systems medicine challenge.

Affiliations: Clinique Universitaire de Pneumologie, Pôle de Cancérologie, Médecine Aiguë et Communautaire, CHU Grenoble, Inserm1055, Grenoble, Université Joseph Fourier, Grenoble, European Institute for Systems Biology and Medicine, EISBM, Lyon, Institut du Thorax, Inserm UMR1087, CNRS UMR629, Service de Pneumologie, CHU de Nantes DHU2020, Nantes, Université de Nantes, Nantes, Université Josep...