Early identification and heritability of mild cognitive impairment

Early identification and heritability of mild cognitive impairment.

BACKGROUND Identifying mild cognitive impairment (MCI) in midlife could improve early identification of Alzheimer's disease (AD). Also, AD is highly heritable, but the heritability of MCI has not been established. We estimated prevalence rates, association with premorbid general cognitive ability (GCA) and heritability for different definitions of neuropsychologically defined MCI in adults in t...

Identification of mild cognitive impairment disease using brain functional connectivity and graph analysis in fMRI data

Background: Early diagnosis of patients in the early stages of Alzheimer's, known as mild cognitive impairment, is of great importance in the treatment of this disease. If a patient can be diagnosed at this stage, it is possible to treat or delay Alzheimer's disease. Resting-state functional magnetic resonance imaging (fMRI) is very common in the process of diagnosing Alzheimer's disease. In th...

Early and Differential Diagnosis of Dementia and Mild Cognitive Impairment

Background: The German Dementia Competence Network (DCN) has established procedures for standardized multicenter acquisition of clinical, biological and imaging data, for centralized data management, and for the evaluation of new treatments. Methods: A longitudinal cohort study was set up for patients with mild cognitive impairment (MCI), patients with mild dementia and control subjects. The ai...

Current development and challenges in biomarkers for early identification of mild cognitive impairment and Alzheimer's disease

Effect of Aerobic Exercise on HbA1c and Cognitive Function in Prediabetes Patients with Mild Cognitive Impairment

Objective: This study aimed to investigate the effects of moderate to high-intensity aerobic exercise on HbA1c (Glycated hemoglobin), FBS (fasting blood sugar) and cognitive function in mild cognitive impairment prediabetes patients. Materials and Methods: Seventeen elderly mild cognitive impairment (age 55-70) men and women were selected and were randomly divided into 2 groups as aerobic (n=1...