منابع مشابه
Fluid Resuscitation in Sepsis: Reexamining the Paradigm
Sepsis results in widespread inflammatory responses altering homeostasis. Associated circulatory abnormalities (peripheral vasodilation, intravascular volume depletion, increased cellular metabolism, and myocardial depression) lead to an imbalance between oxygen delivery and demand, triggering end organ injury and failure. Fluid resuscitation is a key part of treatment, but there is little agre...
متن کاملResuscitation fluid composition affects hepatic inflammation in a murine model of early sepsis
BACKGROUND Fluid resuscitation is a crucial therapy for sepsis, and the use of balanced fluids and/or isotonic albumin may improve patient survival. We have previously demonstrated that resuscitation with normal saline results in increased hepatic leukocyte recruitment in a murine model of sepsis. Given that clinical formulations of albumin are in saline, our objectives were to develop a novel ...
متن کاملA critique of fluid bolus resuscitation in severe sepsis
Resuscitation of septic patients by means of one or more fluid boluses is recommended by guidelines from multiple relevant organizations and as a component of surviving sepsis campaigns. The technique is considered a key and life-saving intervention during the initial treatment of severe sepsis in children and adults. Such recommendations, however, are only based on expert opinion and lack adeq...
متن کاملFluid Resuscitation and Markers of Glycocalyx Degradation in Severe Sepsis
Background The aim of this study was to determine the relationship between fluid resuscitation and glycocalyx degradation in severe sepsis. Methodology 15 post-thoracotomy patients with severe sepsis and 11 patients in recovery after open chest surgery (controls) were enrolled. Results Plasma syndecan-1 concentrations were significantly higher in the sepsis group than that in control group,...
متن کاملFluid resuscitation in human sepsis: Time to rewrite history?
Fluid resuscitation continues to be recommended as the first-line resuscitative therapy for all patients with severe sepsis and septic shock. The current acceptance of the therapy is based in part on long history and familiarity with its use in the resuscitation of other forms of shock, as well as on an incomplete and incorrect understanding of the pathophysiology of sepsis. Recently, the safet...
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ژورنال
عنوان ژورنال: Shock
سال: 2010
ISSN: 1073-2322
DOI: 10.1097/shk.0b013e3181e7e668