Early ERCP for severe cholangitis? Of course!

ERCP in cholangitis.

Navaneethan et al present elegant data examining the variables associated with 30-day readmission in patients undergoing ERCP for cholangitis. However, the methodology used for their statistical analysis deserves critique and has a crucial impact on their findings. The authors introduce the concept of “door to ERCP” time, which seems intuitively to be a powerful measure of clinical success and ...

Establishment of a novel rat model of severe acute cholangitis

Objective(s):This study aimed to establish a novel non-binding, reversible rat model of acute cholangitis of the severe type (ACST). Materials and Methods:Twenty-six rats were randomly divided into the sham-operated group (n=13) and the ACST group (n=13). All rats were intubated with a modified catheter through the external jugular vein. The ACST model was established by ligation of the distal ...

Early ERCP in acute gallstone pancreatitis without cholangitis: a meta-analysis.

CONTEXT Early ERCP was reported to result in recovery from acute gallstone pancreatitis. To date, several RCTs comparing it to conservative treatment have yielded different results. OBJECTIVE We conducted a meta-analysis to determine the effect of early ERCP on the morbidity and mortality of acute gallstone pancreatitis without cholangitis. METHODS We searched the following databases up to ...

Diagnostic and Therapeutic Value of ERCP in Acute Cholangitis

Cholangitis, with a clinical spectrum between acute ascending cholangitis and acute fulminant cholangitis, the mildest and the most severe forms, respectively, is the infection of bile ducts with a potential of serious mortality and morbidity. Obstruction of the bile ducts followed by infection, with E. coli being the most commonly isolated agent, is common to all forms of cholangitis. Biliary ...

Early ERCP in Biliary Pancreatitis?