Early diagnosis of myocardial infarction: why measure cardiac enzymes?

Early diagnosis of myocardial infarction with sensitive cardiac troponin assays.

BACKGROUND The rapid and reliable diagnosis of acute myocardial infarction is a major unmet clinical need. METHODS We conducted a multicenter study to examine the diagnostic accuracy of new, sensitive cardiac troponin assays performed on blood samples obtained in the emergency department from 718 consecutive patients who presented with symptoms suggestive of acute myocardial infarction. Cardi...

Rapid Diagnosis of Acute Myocardial Infarction

To improve the specificity of biochemical markers of myocardial infarction (MI) a method to measure cardiac troponin-I (CTn-I) was developed. CTn-I is a protein unique to cardiac muscle and is released after MI. Consecutive 150 patients admitted to the coronary care unit was studied. Value of CTn-I was determined in all samples. CTn-I concentration in the MI patients group was increased com...

Early diagnosis of myocardial infarction

The rapid and reliable diagnosis of acute myocardial infarction is a major unmet clinical need. We conducted a multicenter study to examine the diagnostic accuracy of new, sensitive cardiac troponin assays performed on blood samples obtained in the emergency department from 718 consecutive patients who presented with symptoms suggestive of acute myocardial infarction. Cardiac troponin concentra...

Why measure cholesterol after myocardial infarction, and when?

Why measure cardiac output?

Although cardiac output is a primary determinant of global O2 transport there are no absolute values that reflect circulatory adequacy, though very low values are of negative prognostic use. There is no agreement as to what constitutes a clinically relevant change in cardiac output. A recent clinical trial suggests that early goal-directed therapy aimed at increasing cardiac output improves sur...