E2F5 status significantly improves malignancy diagnosis of epithelial ovarian cancer
نویسندگان
چکیده
منابع مشابه
Methylation status and immunohistochemistry of BRCA1 in epithelial ovarian cancer.
BACKGROUND Cancer initiation and progression are controlled by genetic and epigenetic events. One epigenetic process which is widely known is DNA methylation, a cause of gene silencing. If a gene is silenced the protein which it encodes will not expressed. OBJECTIVES 1. Identify the methylation status of BRCA1 in patients with epithelial ovarian cancer (EOC)and assess BRCA1 protein expression...
متن کامل[Multidisciplinary management of ovarian epithelial cancer. Radiological diagnosis].
In the context of a multidisciplinary approach for the diagnosis and treatment of ovarian cancer, the contribution of radiology includes the following four fundamental points: identification of the lesion, its characterization, study of its extension and evaluation of its evolution. This article describes the findings and key diagnostic elements in MDCT (Multidetector Computed Tomography) and M...
متن کاملDemographic and Clinical Characteristics of Mucinous Epithelial Ovarian Cancer, and Survival Following a Mucinous Epithelial Ovarian Cancer Diagnosis
Ovarian cancer is the fifth leading cause of cancer death in the United States, and contrib‐ utes significantly to the worldwide cancer burden [1]. The lack of gynecologic-specific symptoms and effective early detection methods for ovarian cancer leads to a preponder‐ ance of late-stage diagnoses. Ovarian cancer is a surgically-staged and treated disease, and the application of appropriate, gui...
متن کاملpromoter methylation status and protein expression of brca2 in patients with epithelial ovarian cancer
background : ovarian cancer is the leading cause of death among gynecological cancers. changes in the methylation of brca1 and brca2 may be an effective mechanism for breast and ovarian cancer. this study evaluates the protein expression and methylation status of brca2 in iranian patients. methods : we assessed 60 mullerian-type ovarian cancers by methylation-specific pcr assays and immunohisto...
متن کاملepigenetic brca2 gene in epithelial ovarian cancer
background ovarian cancer is the most common fatal gynecologic malignancy in women. the brca2 gene has a role in regulation of cell cycle during proliferation, differentiation and dna repair. changes in the methylation of brca2 may be an effective mechanism for ovarian cancer. objectives the aim of the present study was to evaluate the association between ovarian cancer and methylation status o...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2010
ISSN: 1471-2407
DOI: 10.1186/1471-2407-10-64