E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment
نویسندگان
چکیده
منابع مشابه
E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment.
The E2A transcription factors promote the development of thymus-seeding cells, but it remains unknown whether these proteins play a role in T lymphocyte lineage specification or commitment. Here, we showed that E2A proteins were required to promote T-lymphocyte commitment from DN2 thymocytes and to extinguish their potential for alternative fates. E2A proteins functioned in DN2 cells to limit e...
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The E2A transcription factors are required for normal T lymphopoiesis and to prevent T-lymphocyte progenitor transformation. Ectopic expression of E2A proteins in E2A-deficient lymphomas results in growth arrest and apoptosis, indicating that these cells remain responsive to the targets of E2A. Here we identify the transcriptional repressor growth factor independent 1B (Gfi1b) as a target of E2...
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The E2A transcription factors are required for normal T lymphopoiesis and to prevent T lymphocyte progenitor transformation. Ectopic expression of E2A proteins in E2Adeficient lymphomas results in growth arrest and apoptosis indicating that these cells remain responsive to the targets of E2A. Here we identify the transcriptional repressor Growth factor independence (Gfi) 1b as a target of E2A t...
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ژورنال
عنوان ژورنال: Blood
سال: 2013
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2012-08-449447