E-cadherin Interacts With Posttranslationally-Modified AGO2 to Enhance miRISC Activity
نویسندگان
چکیده
Graphical Abstract Regulatory effect between E-cadherin and AGO2.
منابع مشابه
KRAS Engages AGO2 to Enhance Cellular Transformation.
Oncogenic mutations in RAS provide a compelling yet intractable therapeutic target. Using co-immunoprecipitation mass spectrometry, we uncovered an interaction between RAS and Argonaute 2 (AGO2). Endogenously, RAS and AGO2 co-sediment and co-localize in the endoplasmic reticulum. The AGO2 N-terminal domain directly binds the Switch II region of KRAS, agnostic of nucleotide (GDP/GTP) binding. Fu...
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MicroRNA (miRNA)-induced silencing complexes (miRISCs) repress translation and promote degradation of miRNA targets. Target degradation occurs through the 5'-to-3' messenger RNA (mRNA) decay pathway, wherein, after shortening of the mRNA poly(A) tail, the removal of the 5' cap structure by decapping triggers irreversible decay of the mRNA body. Here, we demonstrate that miRISC enhances the asso...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2021
ISSN: ['2296-634X']
DOI: https://doi.org/10.3389/fcell.2021.671244