Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes
نویسندگان
چکیده
منابع مشابه
Exploring intermediate phenotypes with EEG: working memory dysfunction in schizophrenia.
This review brings together two strands of investigation in the neuropsychology and neurophysiology of schizophrenia that have been particularly productive over the last 20 years. We review the literature on working memory deficits, particularly in the visual domain, and changes in oscillatory neural activity as measured with electroencephalography (EEG) and magnetoencephalography (MEG). We arg...
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Dystrobrevin-binding protein 1 (DTNBP1), a gene encoding dysbindin-1, has been identified as a susceptibility gene for schizophrenia. Functioning with partners in synapses or the cytoplasm, this gene regulates neurite outgrowth and neurotransmitter release. Loss of dysbindin-1 affects schizophrenia pathology. Dysbindin-1 is also found in the nucleus, however, the characteristics of dysbindin in...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2016
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.2016.282