Dysregulated Metabolism in Cancer

Metabolism describes the cellular bioenergetic pathways that provide energy and macromolecules for protein, lipid, nucleic acid syntheses. In cancer, malignant cells alter metabolic to acquire nutrients needed proliferation survival. The various modifications exhibited by cancer include aerobic glycolysis, decreased oxidative phosphorylation, elevated production of biosynthetic intermediates. To support increasing need these modifications, increase expressions plasma membrane transporters enzymes involved in pathways. Additionally, some escape chemotherapy treatment reprogramming their activities. This chemotherapy-induced resistance mechanism allows promote survival as well defense against cell damage engaging shunt Therefore, understanding may useful information can further be exploited strategize potential interventions subsequently foster better outcomes among patients with cancer.