Dysproteinemia, proteinuria, and glomerulonephritis
نویسندگان
چکیده
منابع مشابه
A Molecular Signature of Proteinuria in Glomerulonephritis
Proteinuria is the most important predictor of outcome in glomerulonephritis and experimental data suggest that the tubular cell response to proteinuria is an important determinant of progressive fibrosis in the kidney. However, it is unclear whether proteinuria is a marker of disease severity or has a direct effect on tubular cells in the kidneys of patients with glomerulonephritis. Accordingl...
متن کاملProteinuria: From Molecular to Clinical Applications in Glomerulonephritis
Glomerular diseases including diabetic nephropathy are the leading cause of ESRD worldwide. Proteinuria, the hallmark of renal damage in glomerular diseases, is dependent on two main factors: the alteration of the glomerular filtration barrier and its three layers (glomerular endothelial cells, basement membrane, and visceral epithelial cells (podocytes)), and the impairment of proteins reabsor...
متن کاملMassive proteinuria and acute glomerulonephritis picture in a patient with Familial Mediterranean fever and E148Q mutation.
Familial Mediterranean fever (FMF) is an inherited auto-inflammatory disorder. Secondary AA amyloidosis is the most devastating complication of FMF. Nonamyloid renal involvements have also been reported in association with FMF, including vasculitis, focal and diffuse glomerulonephritis, and IgA nephropathy. We describe a patient with FMF and E148Q mutation who presented with massive proteinuria...
متن کاملInflammation augments the development of experimental glomerulonephritis by accelerating proteinuria and enhancing mortality.
Proteinuria represents a parameter for a damaged filtration capacity of the kidney. We investigated how inflammation influences the development of experimental, immune complex-mediated glomerulonephritis by monitoring proteinuria. Mice pre-treated with LPS or TNF, one day before induction of glomerulonephritis, excreted high levels of protein in the urine immediately after the induction of glom...
متن کاملEffect of cerivastatin on proteinuria and urinary podocytes in patients with chronic glomerulonephritis.
BACKGROUND We previously reported urinary podocytes to be a marker of glomerular injury. The aim of the present study was to determine whether cerivastatin, a newly developed, potent synthetic statin, affects proteinuria and urinary podocyte excretion in patients with chronic glomerulonephritis (CGN). METHODS We randomly assigned 40 normotensive hypercholesterolemic patients with CGN to recei...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2006
ISSN: 0085-2538
DOI: 10.1038/sj.ki.5000123