Dysbindin-1 contributes to prefrontal cortical dendritic arbor pathology in schizophrenia
نویسندگان
چکیده
منابع مشابه
The schizophrenia susceptibility gene dysbindin regulates dendritic spine dynamics.
Dysbindin is a schizophrenia susceptibility gene required for the development of dendritic spines. The expression of dysbindin proteins is decreased in the brains of schizophrenia patients, and neurons in mice carrying a deletion in the dysbindin gene have fewer dendritic spines. Hence, dysbindin might contribute to the spine pathology of schizophrenia, which manifests as a decrease in the numb...
متن کاملDysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression.
DTNBP1 (dystrobrevin binding protein 1) remains a top candidate gene in schizophrenia. Reduced expression of this gene and of its encoded protein, dysbindin-1, have been reported in the brains of schizophrenia cases. It has not been established, however, if the protein reductions encompass all dysbindin-1 isoforms or if they are associated with decreased DTNBP1 gene expression. Using a matched ...
متن کاملCortical development and thalamic pathology in schizophrenia.
In this article, morphological data suggesting that brain development may be altered in schizophrenia are reviewed in relation to the major events in neural development. In the absence of severe defects in brain structure in individuals with schizophrenia, developmental processes governing the establishment, refinement, and maintenance of connections are potential sites of pathological involvem...
متن کاملDysbindin-1 Involvement in the Etiology of Schizophrenia
Schizophrenia is a major psychiatric disorder that afflicts about 1% of the world's population, falling into the top 10 medical disorders causing disability. Existing therapeutic strategies have had limited success on cognitive impairment and long-term disability and are burdened by side effects. Although new antipsychotic medications have been launched in the past decades, there has been a gen...
متن کاملDecreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia.
BACKGROUND The pathophysiological characteristics of schizophrenia appear to involve altered synaptic connectivity in the dorsolateral prefrontal cortex. Given the central role that layer 3 pyramidal neurons play in corticocortical and thalamocortical connectivity, we hypothesized that the excitatory inputs to these neurons are altered in subjects with schizophrenia. METHODS To test this hypo...
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ژورنال
عنوان ژورنال: Schizophrenia Research
سال: 2018
ISSN: 0920-9964
DOI: 10.1016/j.schres.2018.04.042