DYNLL1 transcript abundance decreases during oocyte and follicular growth and is associated with fertility in mice

DNA repair efficiency is an important determinant of oocyte quality and female fertility. DYNLL1 (Dynein light chain 1) plays a part in double-strand break (DSB) choice by promoting error-prone non-homologous end joining (NHEJ) contrast limiting accurate error-free homologous recombination (HR) repair. Here, we showed that transcript abundance decreases gradually during follicular growth mice. In parallel, mRNA levels decline the course meiotic maturation Furthermore, our silico analysis ovaries from high-fertility mice with increased ovulation have lower compared control Similarly, found induction human chorionic gonadotropin (hCG) cumulus complexes We hypothesize this decrease might lead to relatively higher HR NHEJ events mice, resulting genome stability. Increased stability also contribute better fertility performance. This paper highlights need for further vivo mechanistic studies understand role down-regulation maintenance reserve