Dynamics and role of MicroRNAs during mammalian follicular development

Dynamics and role of MicroRNAs during mammalian follicular development

Ovarian functions, which involve dynamically regulated processes of selection, recruitment and dominance, are known to be regulated by an array of genes, which are expressed in spatiotemporal manner in follicular somatic cells and gametes. This differential expression of genes in mammalian follicular cells is partly regulated by posttranscriptional gene regulators named microRNAs (miRNAs). In a...

Identification and Characterisation of microRNAs during Bovine Ovarian Follicular Development

.......................................................................................... xiv Research Publications ................................................................... xviii Conference abstracts ..................................................................... xix Chapter 1: Introduction ..................................................................... 2 1.1 Folliculoge...

Insights into role of microRNAs in cardiac development, cardiac diseases, and developing novel therapies

Objective(s): MicroRNAs (miRNAs) are a subfamily of small noncoding RNAs that play a variety of roles in regulating gene expression in nearly all organisms. They affect different biological pathways by post-transcriptionally regulating mRNAs. Aside from miRNAs’  role in maintaining cellular homeostasis, their perturbation is related to several pathologic states and dis...

Steroid Production and Follicular Development of Neonatal Mouse Ovary during In Vitro Culture

The role of microRNAs in mammalian oocytes and embryos.

Advanced genomic analysis has revealed an enormous inventory of non-coding RNAs (ncRNAs), which are functionally important at transcriptional and post-transcriptional level for different cellular processes. Among the ncRNAs, microRNAs (miRNAs) have recently been highlighted extensively for their pivotal role in disease, fertility and development through post-transcriptional regulation of gene e...