Dynamic variation of CD5 surface expression levels within individual chronic lymphocytic leukemia clones

Dynamic variation of CD5 surface expression levels within individual chronic lymphocytic leukemia clones

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of clonally derived mature CD5high B cells; however, the cellular origin of CLL is still unknown. Patients with CLL also harbor variable numbers of CD5low B cells, but the clonal relationship of these cells to the bulk disease is unknown and can have important implications for monitoring, treating, and understanding the bio...

Analysis of VH gene expression in CD5+ and CD5- B-cell chronic lymphocytic leukemia.

In contrast to highly mutated follicular lymphomas and multiple myelomas, chronic lymphocytic leukemias (CLLs) frequently express VH genes in germline configuration. It is currently unclear whether this difference is related to the expression of CD5 or to the differentiation stage of the B cell when malignant transformation occurs. We have studied the VH sequence of 11 cases of CD5- B-CLL to ad...

Analysis of VH Gene Expression in CD5+ and CD5- B-Cell Chronic Lymphocytic Leukemia

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CD5+, CD11C+, trap-positive chronic lymphocytic leukemia/prolymphocytic leukemia.

CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells.

Chronic lymphocytic leukemia (CLL) cells are thought to have diminished cell-cycling capacity, a view challenged by their phenotypic resemblance to activated human B lymphocytes. The present study addresses the cell-cycling status of CLL cells, focusing on those leukemic cells expressing CD38, a molecule involved in signaling and activation that also serves as a prognostic marker in this diseas...