Dynamic susceptibility contrast MRI with localized arterial input functions
نویسندگان
چکیده
منابع مشابه
Dynamic susceptibility contrast MRI with localized arterial input functions.
Compared to gold-standard measurements of cerebral perfusion with positron emission tomography using H(2)[(15)O] tracers, measurements with dynamic susceptibility contrast MR are more accessible, less expensive, and less invasive. However, existing methods for analyzing and interpreting data from dynamic susceptibility contrast MR have characteristic disadvantages that include sensitivity to in...
متن کاملToward local arterial input functions in dynamic contrast-enhanced MRI.
PURPOSE To present a method for estimating the local arterial input function (AIF) within a dynamic contrast-enhanced MRI scan, based on the alternating minimization with model (AMM) method. MATERIALS AND METHODS This method clusters a subset of data into representative curves, which are then input to the AMM algorithm to return a parameterized AIF and pharmacokinetic parameters. Computer sim...
متن کاملDynamic susceptibility contrast MRI
Introduction Quantitative dynamic susceptibility contrast perfusion MRI (DSC-MRI) is based on the monitoring of the first passage of a bolus of contrast agent through the brain tissue and a brain-feeding artery. The contrast agent is injected rapidly by means of an MRinjector in the antecubital vein in the patients arm and a saline flush is used to push the contrast agent into the direction of ...
متن کاملEvaluation of signal formation in local arterial input function measurements of dynamic susceptibility contrast MRI.
Correct arterial input function (AIF) measurements in dynamic susceptibility contrast-MRI are crucial for quantification of the hemodynamic parameters. Often a single global AIF is selected near a large brain-feeding artery. Alternatively, local AIF measurements aim for voxel-specific AIFs from smaller arteries. Because local AIFs are measured higher in the arterial-tree, it is assumed that the...
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Introduction The accuracy in pharmacokinetic parameters derived from Dynamic Contrast-Enhanced MRI (DCE-MRI) depends strongly on the quality of the arterial input function (AIF). The AIF is challenging to measure accurately for several reasons. For example, T1 needs to be determined with a temporal resolution of about one second and with a spatial resolution high enough to resolve the artery wh...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2010
ISSN: 0740-3194
DOI: 10.1002/mrm.22338