Dynamic perfusion and diffusion MRI of cortical spreading depolarization in photothrombotic ischemia
نویسندگان
چکیده
منابع مشابه
Ischemia-induced spreading depolarization in the retina.
Cortical spreading depolarization is a metabolically costly phenomenon that affects the brain in both health and disease. Following severe stroke, subarachnoid hemorrhage, or traumatic brain injury, cortical spreading depolarization exacerbates tissue damage and enlarges infarct volumes. It is not known, however, whether spreading depolarization also occurs in the retina in vivo. We report now ...
متن کاملInterplay between Cortical Spreading Depolarization and Seizures.
Cortical spreading depolarization (CSD) is an electrophysiologic phenomenon found mostly in the setting of neurologic injury resulting in the disturbance of ion homeostasis and leading to changes in the local vascular response. The bioelectric etiology of CSD shares similarities to those in epileptic disorders, yet the relationship between seizures and CSD is unclear, with several studies obser...
متن کاملDiffusion- and perfusion-weighted magnetic resonance imaging of focal cerebral ischemia and cortical spreading depression under conditions of mild hypothermia.
In a model of experimental stroke, we characterize the effects of mild hypothermia, an effective neuroprotectant, on fluid shifts, cerebral perfusion and spreading depression (SD) using diffusion- (DWI) and perfusion-weighted MRI (PWI). Twenty-two rats underwent 2 h of middle cerebral artery (MCA) occlusion and were either kept normothermic or rendered mildly hypothermic shortly after MCA occlu...
متن کاملIschemia Detection using Perfusion MRI
1. Perfusion imaging to detect myocardial ischemia Myocardial ischemia occurs when insufficient blood flow, or perfusion, to the myocardium results in inadequate delivery of oxygen as well as inadequate removal of metabolites. These conditions may occur at rest due to insufficient oxygen supply (supply ischemia) or at stress due to a failure to sufficiently accommodate increased oxygen demand (...
متن کاملPhotothrombotic infarction triggers multiple episodes of cortical spreading depression in distant brain regions.
The purposes of this study were to determine whether cortical spreading depression occurs outside of the infarct produced by photothrombotic vascular occlusion, and also the direction of spreading. Focal cerebral thrombotic infarction was produced by irradiating the exposed skull of anesthetized rats with green light (560 nm) following systemic injection of rose bengal dye. At proximal sites (a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2014
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2014.07.005