Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models
نویسندگان
چکیده
منابع مشابه
Patient-Derived Xenograft Models to Improve Targeted Therapy in Epithelial Ovarian Cancer Treatment
Despite increasing evidence that precision therapy targeted to the molecular drivers of a cancer has the potential to improve clinical outcomes, high-grade epithelial ovarian cancer (OC) patients are currently treated without consideration of molecular phenotype, and predictive biomarkers that could better inform treatment remain unknown. Delivery of precision therapy requires improved integrat...
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Liposomal anticancer agents can effectively deliver drugs to tumor lesions, but their therapeutic effects are enhanced in only limited number of patients. Appropriate biomarkers to identify responder patients to these liposomal agents will improve their treatment efficacies. We carried out pharmacological and histopathological analyses of mouse xenograft models bearing human ovarian cancers (Ca...
متن کاملPatient-Derived Xenograft Models of Epithelial Ovarian Cancer for Preclinical Studies
PURPOSE Patient-derived tumor xenografts (PDXs) can provide more reliable information about tumor biology than cell line models. We developed PDXs for epithelial ovarian cancer (EOC) that have histopathologic and genetic similarities to the primary patient tissues and evaluated their potential for use as a platform for translational EOC research. MATERIALS AND METHODS We successfully establis...
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Elmezzi Graduate School of Molecular Medicine, Manhasset, NY, United States. The Center for 6 Immunology and Inflammation, Feinstein Institute for Medical Research, North Shore-LIJ Health 7 System, Manhasset, NY, United States. Hofstra North Shore-LIJ School of Medicine, Manhasset, NY, 8 United States. Department of Pathology, Massachusetts General Hospital, Boston, MA, United States. 9 Divisio...
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Objective(s): P-glycoprotein (P-gp) is an efflux protein, the overexpression of which has been associated with multidrug resistance in various cancers. Although siRNA delivery to reverse P-gp expression may be promising for sensitizing of tumor cells to cytotoxic drugs, the therapeutic use of siRNA requires effective carriers that can deliver siRNA intracellularly with minimal toxicity on targe...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2016
ISSN: 1471-2407
DOI: 10.1186/s12885-016-2212-6