Dynamic control of endogenous retroviruses during development
نویسندگان
چکیده
منابع مشابه
Dynamic control of endogenous retroviruses during development.
Close to half of the human genome encompasses mobile genetic elements, most of which are retrotransposons. These genetic invaders are formidable evolutionary forces that have shaped the architecture of the genomes of higher organisms, with some conserving the ability to induce new integrants within their hosts' genome. Expectedly, the control of endogenous retroviruses is tight and multi-pronge...
متن کاملEndogenous retroviruses and the development of cancer.
Mammalian genomes include a considerable number of endogenous retroviruses (ERVs), relics of ancestral infectious retroviruses, whose proviruses have invaded the germ-line. The documented ability of infectious retroviruses to cause cancer has greatly contributed to the discovery of ERVs. It also reinforced the concept that ERVs are causative agents of many cancers, a notion that historically ha...
متن کاملEndogenous retroviruses
Endogenous retroviruses are integral features of vertebrate genomes. Here, Hayward and Katzourakis offer a glimpse into the fascinating world of these mysterious partners in our evolution.
متن کاملPorcine endogenous retroviruses: an obstacle to cross during xenotransplantation
Background Xenotransplantation involves the transplantation of nonhuman tissue or organs to humans. Worldwide shortage of organs for clinical applications has shifted the focus towards non-human sources. Pig represents a rich source of organ donors but the presence of porcine endogenous retroviruses (PERVs) represents a particular risk and considered as a major obstacle during xenotransplantati...
متن کاملEndogenous retroviruses and multiple sclerosis.
Endogenous retroviruses are normal constituents in vertebrate genomes. They have been associated with various diseases of presumed autoimmune etiology. However, conclusive evidence of their significance as susceptibility factors in these diseases is still lacking. In our laboratory we have focused attention upon endogenous retroviruses as candidate genes in multiple sclerosis. In this communica...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Virology
سال: 2011
ISSN: 0042-6822
DOI: 10.1016/j.virol.2010.12.007