Dynamic Analysis of Cytokine Profile for Cytokine Release Syndrome in Multiple Myeloma Patients after CAR-T Cell Therapy
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چکیده
منابع مشابه
Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel
BACKGROUND Anti-CD19 CAR T cell therapy has demonstrated high response rates in patients with relapsed or refractory (r/r) B cell malignancies but is associated with significant toxicity. Cytokine release syndrome (CRS) is the most significant complication associated with CAR T cell therapy, and it is critical to have a reproducible and easy method to grade CRS after CAR T cell infusions. DIS...
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UNLABELLED Chimeric antigen receptor (CAR)-modified T cells with anti-CD19 specificity are a highly effective novel immune therapy for relapsed/refractory acute lymphoblastic leukemia. Cytokine release syndrome (CRS) is the most significant and life-threatening toxicity. To improve understanding of CRS, we measured cytokines and clinical biomarkers in 51 CTL019-treated patients. Peak levels of ...
متن کاملTitle: Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T cell Therapy for Acute Lymphoblastic Leukemia
Receptor T cell Therapy for Acute Lymphoblastic Leukemia Authors: David T. Teachey, MD,1,4,8* Simon F. Lacey, Ph.D,6,8,9* Pamela A. Shaw, Ph.D,3* J. Joseph Melenhorst, Ph.D,6,8,9* Shannon L. Maude, MD, PhD,1,4,8 Noelle Frey, MD,5,7,8 Edward Pequignot, MS,6,8 Vanessa E. Gonzalez, M.B.A,6,8 Fang Chen, PhD,6,8,9 Jeffrey Finklestein,6,8 David M. Barrett, MD, PhD, 1,4,8 Scott L. Weiss, MD, MSCE,2 Ju...
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ژورنال
عنوان ژورنال: Blood
سال: 2019
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2019-131799