Dying from within: granzyme B converts entosis to emperitosis

Entosis

What has been your biggest mistake in research? Despite my rant about the importance of risk, I'm not sure that I've taken risks on sufficiently important problems to make really big mistakes. I definitely worry that future studies will show that I've made major misinterpretations of results. For example, several colleagues and I recently showed that the spatial extent of functional magnetic re...

Rescue from granzyme B-induced apoptosis by Wee1 kinase

Granzymes are a family of granule-associated serine esterases that mediate apoptosis by cytotoxic T lymphocytes and natural killer cells. We have previously shown that cdc2, the mitosis-regulating cyclin-dependent kinase, is required for granzyme B-induced apoptosis in target cells. In addition, granzyme B induces premature activation and tyrosine dephosphorylation of cdc2 during apoptosis. Thr...

Entosis enables a population response to starvation

Cell death isn’t just about apoptosis anymore. In the last decade, numerous alternative mechanisms have emerged, including regulated forms of necrosis, as well as entosis, a unique mechanism that is executed as a cell murder rather than cell suicide [1]. Hamann et al. now identify glucose starvation as a key inducer of this noncell-autonomous form of cell death [2]. Cells that undergo entosis a...

Antigen but Lack Granzyme B to Mediate Cytolysis

Entosis Acts as a Novel Way within Sertoli Cells to Eliminate Spermatozoa in Seminiferous Tubule

The present study was designed to investigate the hypothesis that in vivo entosis is a novel pathway for eliminating spermatozoa in the seminiferous tubules (ST) during hibernation of the Chinese soft-shelled turtle. Western blot analysis revealed that the expression of LAMP1 in the testis was significantly higher during hibernation than that during non-hibernation. Immunohistochemistry reactio...