Duration of Dual Antiplatelet Therapy After Coronary Stenting

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Triple Versus Dual Antiplatelet Therapy After Coronary Stenting

OBJECTIVES We evaluated safety and efficacy of triple antiplatelet therapy with aspirin, clopidogrel, or ticlopidine and cilostazol after coronary stenting. BACKGROUND Triple antiplatelet therapy might have beneficial effect to prevent thrombotic complications in patients undergoing coronary stenting. METHODS Patients undergoing successful coronary stenting were divided into dual antiplatelet t...

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Stent thrombosis and optimal duration of dual antiplatelet therapy after coronary stenting in contemporary practice

The introduction of drug-eluting stents (DES) in the practice of percutaneous coronary intervention (PCI) has substantially reduced angiographic and clinical restenosis but is associated with an increasing propensity for very late stent thrombosis (ST). Among several clinical, lesion, or procedure-related predictors of ST, early discontinuation of dual antiplatelet therapy (DAPT) is the most im...

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Short- versus long-term duration of dual-antiplatelet therapy after coronary stenting: a randomized multicenter trial.

BACKGROUND The optimal duration of dual-antiplatelet therapy and the risk-benefit ratio for long-term dual-antiplatelet therapy after coronary stenting remain poorly defined. We evaluated the impact of up to 6 versus 24 months of dual-antiplatelet therapy in a broad all-comers patient population receiving a balanced proportion of Food and Drug Administration-approved drug-eluting or bare-metal ...

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Optimal duration of dual antiplatelet therapy after percutaneous coronary intervention or after acute coronary syndrome

To prevent recurrent ischaemic events, dual antiplatelet therapy (DAPT) is the standard of care after percutaneous coronary intervention and in the treatment of acute coronary syndrome. Recent evidence supports an adjusted DAPT duration in selected patients.The current paper aims to encourage cardiologists to actively search for patients benefiting from either shorter or prolonged duration DAPT...

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Duration of dual antiplatelet therapy after coronary artery stenting: where is the sweet spot between ischaemia and bleeding?

Permanent or transient intraluminal scaffolding of coronary arteries achieved by currently available stents effectively lowers the rate of acute vessel occlusion, persistent dissection, and restenosis. The latter complication is further reduced by local anti-proliferative drug delivery (drug eluting stent, DES), albeit delaying vascular healing with complete re-endothelialization. Blood exposed...

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ژورنال

عنوان ژورنال: Journal of the American College of Cardiology

سال: 2015

ISSN: 0735-1097

DOI: 10.1016/j.jacc.2015.05.053