Duration and Pathologic Correlates of Lewy Body Disease
نویسندگان
چکیده
منابع مشابه
Clinicopathological Correlates of Lewy Body Disease: Fundamental Issues
Lewy body pathology (LBP) is the pathological hallmark of Lewy body diseases, such as Parkinson's disease and Lewy body dementia. Recent studies have shed new light on the role of LBP, the interactions of LBP with concomitant pathologies, and the propagation of LBP from the olfactory bulb and enteric nervous system to the central nervous system. The intrinsic difficulty with identifying clinico...
متن کاملLewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype.
BACKGROUND The origin and significance of Lewy bodies and neurites (Lewy body pathology [LBP]) in Alzheimer disease (AD) are poorly understood. OBJECTIVE To examine LBP in the brainstem, limbic cortex, and neocortex of a large number of familial AD cases with mutations in 2 presenilin (PSEN) genes. METHODS Twenty-five familial AD cases with 9 known PSEN 1 mutations and 14 familial AD cases ...
متن کاملCortical Lewy body disease.
C ortical Lewy body disease is a pathological observation rather than a distinct clinicopathological entity. Cortical Lewy bodies (CLB) are typically found in Parkinson’s disease and dementia with Lewy bodies (DLB), although they may also occur in other neurological disorders. Unlike their brain stem counterparts, CLB are less distinctive and are poorly visualised using conventional histochemic...
متن کامل[Diffuse Lewy body disease].
Diffuse Lewy body disease (DLBD) has been studied from various viewpoints and, although clinical diagnostic criteria for DLBD have been proposed, diagnosis remains difficult. DLBD has been reported to be the second most common form of dementia in the aged, following Alzheimer-type dementia. It has, however, been clinically under-diagnosed. Therefore, the search for diagnostic markers for DLBD m...
متن کاملCognition and Lewy body disease.
INTRODUCTION We're assisting in last years to an important change in clinical manifestations of Parkinson disease. Nowadays motor symptoms have best treatments if we compare with those existing some decades ago, which in last term, permits other manifestations being the main disabilities in an advanced Parkinson disease. Among these disabilities cognitives are the most severe due to it's preval...
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ژورنال
عنوان ژورنال: JAMA Neurology
سال: 2017
ISSN: 2168-6149
DOI: 10.1001/jamaneurol.2016.4926