Dual-Selective Catalysis in Dephosphorylation Tuned by Hf6-Containing Metal–Organic Frameworks Mimicking Phosphatase

Selective dephosphorylation of proteins containing phosphotyrosine by alkaline phosphatases.

SELECTIVE GROUPOIDS AND FRAMEWORKS INDUCED BY FUZZY SUBSETS

In this paper, we show that every selective groupoid induced by a fuzzy subset is a pogroupoid, and we discuss several properties in quasi ordered sets by introducing the notion of a framework.

Dual-specificity phosphatase 23 mediates GCM1 dephosphorylation and activation

Glial cells missing homolog 1 (GCM1) is a transcription factor essential for placental development. GCM1 promotes syncytiotrophoblast formation and placental vasculogenesis by activating fusogenic and proangiogenic gene expression in placenta. GCM1 activity is regulated by multiple post-translational modifications. The cAMP/PKA-signaling pathway promotes CBP-mediated GCM1 acetylation and stabil...

Interacting Frameworks in Catalysis

In current OO Design, most of the existing (semi-formal) methods use classes or objects as the basic unit of design. However, it is increasingly recognised that classes are not the best focus for design. Typical design artefacts are about groups of objects and the way they interact. In the Catalysis project, we use the term frameworks for descriptions of groups of objects, their relationships, ...

Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase.

Cytokine-induced tyrosine phosphorylation of the transcription factor STAT5 is required for its transcriptional activity. In this article we show that the small dual-specificity phosphatase VHR selectively dephosphorylates IFN-alpha- and beta-activated, tyrosine-phosphorylated STAT5, leading to the subsequent inhibition of STAT5 function. Phosphorylation of VHR at Tyr(138) was required for its ...