Dual degradation signals control Gli protein stability and tumor formation
نویسندگان
چکیده
منابع مشابه
Ruminal Protein Degradation and Estimation of Rumen Microbial Protein Production
Animal agricultural production systems are major sources of nonpoint pollution affecting quality of water sources. Nitrogen has been identified as the foremost source of nonpoint water pollution and the potential negative impacts of N have become an area of public concern. protein degradation from feed ingredients is an important factorinfluencing AA supply to the duodenum. Ruminal proteolysis...
متن کاملRuminal Protein Degradation and Estimation of Rumen Microbial Protein Production
Animal agricultural production systems are major sources of nonpoint pollution affecting quality of water sources. Nitrogen has been identified as the foremost source of nonpoint water pollution and the potential negative impacts of N have become an area of public concern. protein degradation from feed ingredients is an important factorinfluencing AA supply to the duodenum. Ruminal proteolysis...
متن کاملWnt signals are targets and mediators of Gli function
There is growing evidence that Gli proteins participate in the mediation of Hedgehog and FGF signaling in neural and mesodermal development. However, little is known about which genes act downstream of Gli proteins. Here we show the regulation of members of the Wnt family by Gli proteins in different contexts. Our findings indicate that Gli2 regulates Wnt8 expression in the ventral marginal zon...
متن کاملProtein degradation and protein synthesis in long-term memory formation
Long-term memory (LTM) formation requires transient changes in the activity of intracellular signaling cascades that are thought to regulate new gene transcription and de novo protein synthesis in the brain. Consistent with this, protein synthesis inhibitors impair LTM for a variety of behavioral tasks when infused into the brain around the time of training or following memory retrieval, sugges...
متن کاملDual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation
Overexpression of the GLI1 gene has frequently been found in various cancer types, particularly in brain tumors, in which aberrant GLI1 induction promotes cancer cell growth. Therefore, identifying the molecular players controlling GLI1 expression is of clinical importance. Previously, we reported that AMPK directly phosphorylated and destabilized GLI1, resulting in the suppression of the Hedge...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genes & Development
سال: 2006
ISSN: 0890-9369
DOI: 10.1101/gad.1380906